What are the first signs of Parkinson's disease?

It is not known precisely the causes that cause changes in Parkinson's disease. However, some of the mechanisms responsible for the appearance of characteristic symptoms have been elucidated. Parkinson's disease occurs when numerous loss occurs, especially from a portion of the brain that is called the black substance. Neurons at this level use dopamine to transmit information about body movement to the next relay. The second structural disorder of the brain that is commonly found in Parkinson's disease is the presence of Lewy bodies. These are deposits of proteins inside the nerve cells, their role in the pathogenesis of the disease is still unknown.

Another neurophysiological change that may occur in people with Parkinson's disease is loss of nerve endings that have norepinephrine (noradrenaline) as a neurotransmitter. This substance is a mediator of, responsible for the autonomic functions of the body (such as blood pressure). Environmental risk factors associated with Parkinson's disease are: - Exposure to pesticides and herbicides - may increase the risk of disease and by 80% - Neighborhood of the home with industrial factories or quarries - Fountain water consumption - Metal exposure - manganese and lead Exit and . During the illness, symptoms can occur from three major categories: - Motors - Neuropsychiatric - Autonomous Typically, motor symptoms initially affect only one half of the body and as the disease progresses, the whole body is affected. As major motor changes: - is present at rest and disappears during sleep; .

If the patient is at a more advanced stage of the disease, he may report problems with balance, cramps and muscle stiffness. Non-motor symptoms often occur since the onset of the disease. The clinical examination will evaluate the motor, neuropsychiatric or autonomic signs that may occur during Parkinson's disease. .