The link between obesity and colorectal cancer

Colorectal cancer is an increasing disease in adults. Although causes vary, a global study involving Mayo Clinic, Fox Chase Cancer, and the National Cancer Institute attests to a direct link between obesity and increased risk of developing colorectal cancer! . Genetic replacement of this hormone has transformed tumor suppressors and prevented cancer development - even when mice continued to eat excess calories. These findings place the use of linlastoid (Linzess), which is structurally linked to the lost hormone, as a therapeutic approach to the prevention of colorectal cancer in obese patients, The risk of developing colorectal cancer in obese people is approximately 50% higher compared to the risk for normal weight. Scientists believed that the problem was based on the amount of fatty tissue and associated metabolic processes involved - the excess of calories that energize and increase the energy of the cells - but this has not proved to be real in the present case, Dr. Waldman.

Dr. . Waldman is already involved in a clinical trial and in the side effects of lincollotide use in healthy volunteers. Investigators at the National Cancer Institute, Mayo Clinic and the Fox Chase Cancer Center also participate in this study. Up to now, it has been discovered that obesity (either from excess fat or carbohydrate consumption or both) is associated with the loss of guaniline, which is produced in the intestine epithelium.

The hormone starts its receptor (GUCY2C), which in turn regulates the processes underlying the regeneration of the intestinal epithelium. The mucosa of the intestines is dynamic and continuously regenerated, and GUCY2C contributes to the correct functioning of the key processes required for this regeneration, Dr says. Waldman. Deactivation of the guaniline gene is common in colorectal cancer cases in both humans and animals, he says. In this regard, obese patients show a decrease of up to 80% in the expression of guaniline genes compared to normal weight.